Unless you have a vintage computer with Windows 98 or earlier, you will not get "The Dame" running in DOS mode.
On a modern computer it should be run inside DOSBox.
If you're not able to configure it, and you REALLY want to play it, there is the +1click guy at eBay (aka allvideo), who supplies original discs along with his custom installer.
http://www.ebay.com/itm/231154503708Blade Runner is a Windows 95 game and won't run in DOSBox.
It may run inside Virtual PC or VMware Player.