When I worked in the laptop repair department at a local community college, some of the laptops students brought in had well over 10,000 threats/pups/issues/whatever-you-call-them. We used a combination of Symantec, MalwareBytes, Spybot, and occasionally ComboFix to try to clean the laptops. Occasionally some of them had infections so deep that nothing could clean them, and the laptops had to be formatted and Windows reinstalled.
We also saw instances where there were so many toolbars that you could hardly see the actual webpage. They rivalled the mess in this screenshot
http://www.itguyswa.com.au/wp-content/uploads/2013/11/too-many-toolbars-IE.jpgThese were college students around 20 years old (give or take a couple of years), not older people who grew up in a different era without computers. You'd think the students would have learned how to use a computer better. Unfortunately protecting themselves against malware doesn't seem to be something that is normally considered as a required course in schools, even though using a computer for school is pretty much a requirement now.