The walkthrough that mentioned keyboard keys for the 2001 Jekyll and Hyde was this one
http://www.gameboomers.com/wtcheats/pcJj/JekyllandHyde.htmlin the introductory paragraph.
You have to go the configurations to set up your keyboard to move Jekyll and Hyde around. I use the keys they suggested and it seems to work fine for me. I will have to say when I played the game the second time I did much better. There are three keys that are important. The first is the "S" key for lining up your jumps so the object you are jumping to fits in the middle of the screen. You can move both Jekyll and Hyde a tiny bit if you are careful pushing the arrow keys. The "Q" and the "D" key are for camera angles. There are places in the game where you can’t use them. So don’t be alarmed when you see a red "X" on them.
So it might be possible to remap some of the keys.
You might have to remap the "S" key first though, before attempting to map the arrow keys to WASD.
I couldn't find a manual for the game at replacementdocs. If you have the manual, it may or may not have instructions for remapping keys.
Good luck with it.