I would think trying to use a saved game would be much harder then working the knife in the game. Try the following. Can you see the end of the knife in the slot of the screw as the second screenshot shows it in my walkthrough?
Click on the link below: Does it look like this when you try to turn it? Turning the screw
If it does then left mouse button click on the knife (hold the mouse button down - keep it down), then (while still holding the left mouse button down) trace out or draw circles with your mouse on the mouse pad as the green circle with arrows shows in the picture above some seven or eight times. As You circle you mouse on the mouse pad to the left (sill holding down left mouse button) you should see the screw turning.
Experiment with this because this kind of mouse action shows up in other puzzles later in the game