The closest directory I have to that is C:\Users\Owner\AppData\Roaming, and Sherlock Homes isn't in there.

Try right-clicking the game shortcut on your desktop and choose "Launch as Administrator". See if that makes a difference. Also try the hidden folder tip in my last post.

I did right click the shortcut and the computer said disc could not be found, I pressed acticvation and is asked for a serial number. I have no clue where that is.

Has anyone seen my latest response? Until I can figure this part out, I can never play ;(

Jen

Post at Glitches forum. They know more about Vista and games.
Explain to them your problem. They might be able to help you.

Im having a problem with one of the puzzles, i need to choose letters to come up with an answer that Watson found at the hospital. this game is being run on Vista. I can't see any letters, I've right clicked the shortcut and chose "Run as Administrator" but the computer can't find the disc. I'm very bad at working out computer problems, so if anyone can help me, I'd really appreciate it.

Jen

I think this is more of a Hints problem -- a matter of figuring out how to work the interface that lets you see the letters. I can't remember exactly how I did it when I played the game. I'll move this over to Hints.

Sorry for the trip around the forums.

Let's try working on making your resolution smaller - please play with the options to see if you can make the screen smaller.
Also best to replay that puzzle and be sure that you have selected the correct 2 documents. Verify by checking the tabs at top left page.

I went through all the resolutions and still had the same problem with no letters to solve the puzzle. I was sent what looks like a gif of Watson but neither me nor my husband know what to do with it. I did select the correct documents using the WT

Jen

This walkthrough is in German - look at all the pictures and follow them - see if that works for you - click here.

Okay, got it, let's see if it works. Thanks for the info and I'll let you know the results

Jen

I got it!! Apparently I didn't choose the animals in the documents. I finally got through. and even without the German WT Thanks so much!!!

Jen

Phew! Glad you finally found what was holding you back.

Enjoy the rest of the game now.

sorry I was such a pain in the behind

You weren't a pain. It's wonderful when a seemingly insolvable problem gets resolved eventually.