If you can handle Skyrim, you will have no problems with The Witcher. Like l4l says, the combat is a little different, but I grew to really, really like it. There seemed to be more "finesse" to it rather than just hacking and slashing away. And, oh, yes. I'll be interested to see if you become completely infatuated with Geralt like the rest of us did!
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If life gives you lemons, make lemonade. If life gives you tomatoes, make Bloody Marys.