I took out my old saves and yes, you use E to fire a pistol. You must choose it in your inventory as the weapon to use in your left hand as opposed to sand or coconuts to throw. With a sword in my R hand, I shot my pistol using E Now you cannot aim with a pistol, it is the game who aims for you. I remember using it only when in deep trouble. I just found a muskett in my inventory: placed it in my R hand instead of the sword and... voila!!! It works like my sword using middle button on my mouse!!! I was quite surprised as I have not played this game in months, as I lost interest in the middle of it!!!
Correction: Had A shotgun, put it in R hand, arm it with middle mouse, aim with R mouse, shoot with left mouse.
Edited by Jacline (12/01/12 11:20 AM)
Edit Reason: correction