1st off : Do not worry or bother with the .nfo file, it is just an information file written by the software crackers on how to install the NoCd fix, although the information is not always helpful, as there is a lot Garbage or Codes written before and after the instructions and sometimes tend to written for those who burn ISO DVDs or other stuff.
If you want to see the contents, just replace .nfo with .txt, you will get a Warning about changing the Extension, just ignore it and open the file and you will see for yourself.
As for the NO CD fix itself, I noticed that there were 2 versions re: EXE #1 and #2, you might have to try both.
In any case, just simply unzip the main.exe from the rar folder and copy it to your game directory, it should ask you to Overwrite the main.exe file that already exist.
Speaking of which, before overwriting your own main.exe file, you should copy it to a safe place in case either one does not work for you and you need the original one back without having to re-install your game.
And yes, Remove the CD, you should not need after installing the NO CD fix.