It would depend on what you're talking about, petjo. If you're talking about a tablet with a detachable keyboard or a laptop with an attached keyboard - both assuming a touch screen - you would be able to play the game normally with keyboard and mouse. However, that would assume you have a touch tablet or a touch screen laptop with enough hardware - processor, video card etc. - to play such games.
If you're talking about Windows 8 on a regular desktop - again with sufficient hardware - yes, you can play with mouse and keyboard. I am playing Tomb Raider Underworld on my Windows 8 right now.
Heading for the gardens!