Just escape and then click on the S for save. It will make a new save with a new picture. Plus, it keeps all the old ones so you can load up a previous save if you want. I am a chronic "saver" when it comes to games like this and have dozens of them.
I'm playing on the hard setting right now, but I remember not being able to get through the big boss fights in the easy setting the first time I played unless I used cheats!
Some day I'll get up the nerve to play it on the nightmare setting!
I have a gazillion saves, so let me know if you're having any problems in a sticky place.
Heading for the gardens!