Windows Defender is what Windows 8 calls the Microsoft antivirus. I haven't found any forum threads from 2016 saying there is a problem between Windows 8 and the Steam client, though there are many from 2013, 2014, and earlier.
You might see if the information here works, even though it's from 2014 -- verifying the integrity of the game cache...
https://steamcommunity.com/app/295270/discussions/0/619569341117066262/