I haven't had any luck finding information on getting this game working on Windows 10. In fact, none of the download sites I checked that sell this game (Fireflower, Steam, Amazon, Big Fish) claim it works on anything later than Windows 8 (and Amazon only claims up to Windows 7). Now it might work on some peoples' computers but not on most, or parts of the game might work but it might not be finishable, but none of those sites support the game on Windows 10.
It's also not on Gameboomers' "Windows 10 and Games" list.
http://www.gameboomers.com/forum/ubbthreads.php/topics/1027119/1I did not think about the antivirus. but if it was working in the first part of the game I don't think that interfered. Would it interfere after the game has started working?
It might. By default an antivirus will scan everything your computer is doing and block things it thinks are suspicious, including games, or things games do during play. You could try adding the game exe to your antivirus' exceptions list to see if that helps.
If you have a save from before the game messed up, go back to that one. Otherwise you'll have to replay from the start. If Mina didn't bandage her leg when she should have, something didn't trigger properly, so you have to go back to before that happened.
Another thing to try is to start the game by right-clicking the game shortcut and choosing "Run As Administrator."