Okay, now what you are going to do is to double-click on that file - when I did that, I got a message from Windows saying that it couldn't open the file or some such thing and do you want to choose a program that will open it for you. Choose Notepad ++ (or whatever version of Notepad you have). After you say you want to open it with Notepad, you should then be looking at the DOSBox configuration file.
Then, go down to line 49 and you will see a line that says this:
memsize=16
What you are going to do is to change the number 16 to the number 32, so that the line looks like this:
memsize=32
After you have made this change, be sure to SAVE this change by hitting Control + S. Once you have saved the information, you can exit out of this dosbox config file and you are done.
Then start up
Pandora Directive again and see if the game crashes. I am hoping that this will fix your problem.
Let me know how it goes.