Bait and switch: Each clue below can be answered by changing one letter in the given, capitalized word, and then anagramming the letters. Some easy, some may be alterative spellings, hyphenated or Britspeak, and a few that may need the Stitchionary. There may even be the odd two-word answer...
Plenty to go round, so feel free to grab a couple
PANTHER-1. Rope used to tie up boat
-2. Progenitors
-3. Part of a set of bagpipes
-4. Enchant, captivate
-5. Repeated motif
-6. Head covering
-7. To make or become cheerful
-8. William _____, actor (?)
-9. Additional
-10. Light 19th century horse-drawn carriage
-11. Web-based music-streaming service
-12. Sub-division of a book
-13. To turn the wrist or arm so that the hand faces palm-down
-14. Seaport in N Belgium
-15. Made of baked clay
-16. Lures into performing an illegal act
-17. Saturated hydrocarbon formula C7H16
-18. Warm (as with an oven) in advance of cooking
-19. Being changeable in shape or form
-20. Anticoagulant
-21. Part of a horse's foot between the fetlock and the hoof
-22. Raise the pitch of a note by one chromatic semitone
-23. Have reference or relation to
-24. Argues with, rebukes
... lose the N in exchange for an S-25. Decorative container for horticultural use
-26. Treatment of disease or disorder
-27. Discover, bring to light