Hi Razzle --
I played this one years ago. I remember the cheese! (You are adrift in space when you're trying to get it to squirt, right?)
Another idea -- have you "examined" the Cheese Girl to find the info that it is made of pressurized Cheese? You may need to have that info before it'll work.
I'm not sure about the squirting, but the saving issue does sound more like a glitch. Would you want to post that problem in the Glitches forum to see if the experts there can help?
EDIT: I just remembered that I have the Buried in Time Official Strategy Guide -- thought I'd have a look for how to save your game.
You know what? The Guide has 258 pages, and not one mention of how to save your game.
Sheesh!