It depends on which Mac version the game disc calls for.
There is an emulator called Basilisk II that supports up to Mac OS 8.1
https://en.wikipedia.org/wiki/Mac_OS_8Basilisk II has versions for Windows and Linux as well as Intel Macs.
https://en.wikipedia.org/wiki/Basilisk_IIhttp://basilisk.cebix.net/I would not say it was easy to set up.
Mac System 7 was made a free download by Apple, which hosted the install files for a time (may still be on their site somewhere)
https://en.wikipedia.org/wiki/System_7http://igsi.tripod.com/mac/index753.htmThere are instructions here
http://emaculation.com/doku.php/basilisk_ii_setupMac OS 8 install CD's are harder to find now and more expensive than when I got mine.
You'd probably also have to install a program to enable the PC to read Mac CD's. I've never set up Basilisk on a PC, only on an Intel Mac which didn't have problems reading Mac CD's.
There is also a Sheepshaver for Windows emulation program that can run up to Mac OS 9 (if you happen to have an OS 9 CD).
https://en.wikipedia.org/wiki/Sheepshaverhttp://www.emaculation.com/doku.php/sheepshaver_setup------------------
There are some "hybrid" game CD's that can be used on both PC and Mac. For example, Frankenstein: Through the Eyes of the Monster, Mummy: Tomb of the Pharaoh, Journeyman Project 3, Symbiocom, The Crystal Skull, Lighthouse, Chaos: A Fantasy Adventure game, Myst (original version), Riven, The Last Express, and many edutainment titles like Genesys, Physicus, Bioscopia, Chemicus, Opera Fatal, Vikings, and Crusader. Early QuickTime made it easy to make games for both PC and pre-OSX Macs. Other games have separate discs for the Mac and PC versions (Myst Masterpiece, Amber: Journeys Beyond, 9: The Last Resort, Obsidian, Zork Nemesis, Return to Zork, RAMA, Ripper, Shivers, Timelapse, Riddle of the Sphinx, etc.)
At the time I tried out Sheepshaver and Basilisk on my iMac, there was a problem with the emulators reading hybrid CD's. This may have been solved by now, but you'd be better off using something like VMware or VirtualPC to play those hybrid disc games anyway.