Talking parrots in any game.
Oh, bother!
If a different voice was used for a parrot (say a Sean Connery voice) I could change my mind!
My 1st choice for most obnoxious character would be the receptionist in Carte Blanche! I forgot about awful parrot voices - I think it would be wonderful nickie if they sounded like Sean Connery or maybe Tim Curry - if I thought I could think of a few other actors too!
Have to agree with the suffrajester in Discworld & Mustavio in Keepsake but have always been surprised that the main character in Tunguska irritated so many others - didn't have a problem with her at all!!! But to add - one voice that really drove me nuts was the wife in The Watchmaker. She was just so monotonous & dreary!