ScummVM now runs the first 15 Nancy Drew games, if you care to try it:
ScummVM I am sure you could watch a YouTube video showing how to set this up and get a game running. You would need to use your original CD.
I have the Danger by Design download from Big Fish and it works just fine.
I would also ask if you have tried these instructions from HeR Interactive:
How to Install Older ND Games on Windows 10Many people have found the HeR Interactive instructions helpful.
By the way, you might be interested to know (if you don't know already) that Big Fish is releasing Mystery Case Files: Dire Grove Remastered (probably next month) that will run on Windows 10 and higher.