My favorite N.D. games so far (I haven't played very much of Crystal Skull so can't say about that) have been:
Curse of Blackmoor Manor, Royal Tower, Secret of the Old Clock and Message in a Haunted Mansion due to the settings. I loved roaming around the old mansions and I loved the history. Followed closely by Secret of the Scarlet Hand.
I must admit that the later games having me do all the chores hasn't been my cup of tea. I have played all except White Wolf which just turned me off with all the chores - if I wanted to clean it would be my house first
But I do reserve the right to play the game later.