1) As for your Malwarebytes not seeming to work, reboot or restart your computer, when all is up and running you should see the blue Malwarebytes icon on your taskbar if it is activated in your taskbar functions. Once you get that fixed, right click on your MB icon and on the pop up click on Update and follow instructions if needed.
2) If it is not a hardware issue as suggested by Trail_Mystic awhile back, then the other solution and it is not a fun one but one that could help is to back up everything you want to keep, etc. and then do a Fresh Install of Windows.
3) Good luck