...These are the exact messages I get on my computer...
first: Stream: attribute 'Showhotspots' doesn't exist on node 'Profile'
second: Runtime Error
This application has requested the runtime to terminate in an unusual way. Please contact the application's support team for more information.
I can't find that exact message with a Google or Bing search. I found something about attributes that had to do with XML code. I'm not sure, but 'Showhotspots' might have something to do with a hotkey that toggles showing hotspot locations on and off.
My guess is that your Windows or your antivirus prevented the game from saving your profile correctly when you exited after playing that first time. Or it may have prevented the game from accessing the profile when you restarted the game.
You can try restarting the game, like Barry did. It might help to reboot first (or it might not).
You can try uninstalling and reinstalling. But after you uninstall, make sure the game didn't leave a folder with a (corrupt?) configuration file behind.