I played Amerzone from the App Store on my iMac a couple of years ago and it works fine. However, I found it to be a little "watered down" from the original version. Some of the puzzles were not there, or already pre-solved, and some locations were not available. But it's still a great game and I enjoyed it a lot. In fact this discussion has inspired me to play it again.
It's definitely "watered down" as compared to the original, both on Mac OSX and on iPad.
I found it very frustrating that I couldn't explore the way I did on the original PC version, and didn't bother finishing it. Instead I replayed the PC version on an old computer, where I was able to explore and look at everything. The PC version might work in VirtualPC, but I haven't tried it.