The game is Vista compatible - have you checked the disc for smudges and scratches?
Every optical reader handles errors a bit differently, it's possible the CD is marginal or the Vista CD drive is going bad.
Give it a good cleaning and see if it recognized on the Vista PC.
Edit -
What happens if you try to open the CD from Windows Explorer (or Computer)?
Last edited by InlandAZ; 02/04/10 12:22 AM.